N-Heterocyclic Carbene Catalyzed Enantioselective Annulation of Benzothiazolyl Ethyl Acetates with 2-Bromoenals.
نویسندگان
چکیده
An N-heterocyclic carbene catalyzed enantioselective [3+3] annulation of benzothiazolyl acetates with 2-bromoenals has been developed. The protocol provides a direct asymmetric synthesis of dihydro-1H-benzothiazolopyridinones in good to very good yields and medium ee values. In many cases, the virtually enantiopure heterocycles are available through a single recrystallization (99% ee).
منابع مشابه
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ورودعنوان ژورنال:
- Synlett : accounts and rapid communications in synthetic organic chemistry
دوره 26 11 شماره
صفحات -
تاریخ انتشار 2015